دکتر بیتا ضمیری

Education:

Doctor of Philosophy – Pharmaceutical Sciences 
Sep. 2011 – June 2016
University of Toronto, Toronto, ON


Bachelor of Applied Science – Chemical Engineering                                                    
Sep. 2006 – Dec. 2010
University of Tehran, Tehran, Iran



 
Publications:

Kalaak Reddy, Bita Zamiri, Sabrina Stanley, Robert B. Macgregor Jr. and Christopher E. Pearson.
The disease associated r(GGGGCC)n from the C9orf72 gene forms tract length-dependent uni- and multi molecular RNA G-quadruplexes. Journal of Biological Chemistry (JBC) (Impact factor: 4.57), April 5, 2013
 Bita Zamiri, Kaalak Reddy, Robert B. Macgregor Jr. and Christopher E. Pearson.
TMPyP4 distorts RNA G-quadruplex structures of the disease associated r(GGGGCC)n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteins.  Journal of Biological Chemistry (JBC), (Impact factor: 4.57), December 26, 2013 (selected as the cover of the JBC journal)
 Bita Zamiri, Mile Mirceta, Karol Bomsztyk, Robert B. Macgregor Jr. and Christopher E. Pearson.
Quadruplex formation by both G-rich and C-rich DNA strands of the C9orf72 (GGGGCC)8.(GGCCCC)8 repeat: Effect of CpG methylation. Nucleic Acids Research (NAR). (Impact factor: 9.2) October 2, 2015. (Featured in ALS Canada Research and selected as the cover of NAR journal)
 Yun Li Yang , Rashid Abu-ghazalah, Bita Zamiri and Robert B. Macgregor Jr.
Concentration-dependent conformational changes in GQ forming ODNs. Biophysical Chemistry. (Impact factor: 2.36) February 17, 2016.
Taro Ishiguro, Nozomu Sato, Nobuhiro Fujikake, Chantal Sellier, Akemi Kanegami, Morio Ueyama, Takanori Yokota, Keiji Wada, Bita Zamiri, Terrence Gall-Duncan, Mila Mirceta, Christopher E. Pearson, J.Paul Taylor, Nicolas Charlet-Berguerand, Hidehiro Misusawa, Yoshitaka Nagai and Kinya Ishikawa.
Regulatory role of RNA chaperone TDP-43 for RNA misfolding and repeat-associated translation in SCA31. Neuron (Impact factor: 15.05) April, 5, 2017
Taro Ishiguro, Nozomu Sato, Nobuhiro Fujikake, Chantal Sellier, Akemi Kanegami, Morio Ueyama, Takanori Yokota, Keiji Wada, Bita Zamiri, Terrence Gall-Duncan, Mila Mirceta, Christopher E. Pearson, J.Paul Taylor, Nicolas Charlet-Berguerand, Hidehiro Misusawa, Yoshitaka Nagai and Kinya Ishikawa.
Balance between RNA binding proetin TDP-43 and an RNA UGGAA repeat underlies pathogenesis of spinocerebellar ataxia type 31 (SCA31) and motor neuron disease fly models. Jounral of Neurological Sciences (Impact Factor: 2.474) October 15, 2017
Hasan Y. Al-Niss, Bita Zamiri, Melissa Khalaj, Chritopher E. Pearson and Robert B. Macgregor Jr.  
Thermodynamic and spectroscopic investigations of TMPyP4 association with guanine- and cytosine- rich DNA and RNA repeats of C9orf72. Biochem Biophys Res Commun. (Impact factor: 2.29) Jan 22, 2018
Bita Zamiri, Mila Mirceta, Rashid Abu-ghazalah, Mark Wold, Christopher E. Pearson and Robert B. Macgregor Jr.
Stress-induced acidification may contribute to formation of unusual structures in C9orf72 repeats. Biochim Biophys Acta. (Impact Factor: 4.7) March 15, 2018
Javad Mokhtari, Maryam Nourisefat, Leila Fotouhi, Bita Zamiri, Amir-Hassan Zarnani, Aliakbar Moosavi-Movahedi and Khashayar Karimian
Mate and Separate: Isolation and Purification of biological molecules in homogeneous systems by phase transition of their PEGylated recognition counterparts, Under Review, April 2019
Mate and Separate Technique, National Patent Pending, March 2019
Javad Mokhtari, Maryam Nourisefat, Leila Fotouhi, Bita Zamiri, Amir-Hassan Zarnani, Aliakbar Moosavi-Movahedi and Khashayar Karimian